I’ve been taking creatine for a while. Five grams in the morning, maybe an extra scoop on lifting days, the standard protocol most people follow. You hear it helps with the gym, you throw it in your protein shake, and you don’t think much more about it.
That changed after I listened to this episode on longevity and brain health. The conversation around creatine has moved way past the gym, and I had no idea.
Since then I’ve been upping my dose, and I’ve noticed a real difference cognitively. The first time I really tested it was after a long flight on not a lot of sleep. I took 20g spread throughout the day and felt more alert than I had any right to be. Not wired, just not dragging the way I normally would. The tiredness that usually follows me off a plane wasn’t there the same way. I’ve been paying attention ever since.
The old story is only half the story
Your liver makes about 1–3 grams of creatine per day. Your muscles are the greediest consumer. They store it and use it to regenerate energy fast, which is why it works for the gym: more reps, faster recovery, more training volume. Supplement with 5g/day for a few weeks and your muscle stores are saturated. That’s the version of the story everyone knows.
What nobody was leading with: your brain makes creatine too. It needs it. And under any kind of stress — sleep deprivation, jet lag, high cognitive load, a season where you’re just running on empty — your brain’s demand for energy spikes and its creatine supply falls short.
At 5g/day, your muscles take almost all of it. Anything above that starts spilling over to the brain. Research out of RWTH Aachen University in Germany found that 10g/day increased creatine levels in multiple regions of the brain. That’s the window where the brain benefits actually kick in.
The sleep deprivation data is what got me
A study published in Scientific Reports sleep-deprived participants for 21 hours, then gave them a high dose of creatine. Not only did it completely offset the cognitive deficits of sleep deprivation, they performed better on memory and processing tasks than people who were fully rested. I had to reread that a couple times.
There’s also a published double-blind trial where people with depression who supplemented with creatine alongside cognitive behavioral therapy had significantly greater reductions in their depression scores than those who did CBT alone. Depression is a form of brain stress, and creatine appears to help the brain make energy faster under that kind of load.
What my protocol looks like now
- Regular days: 5g in the AM (sometimes 2 scoops), plus an extra scoop in my protein shake on workout days
- Demanding days with travel, jet lag, early mornings, long shooting days: 20g spread throughout the day
I’ve also noticed some muscle definition as a side effect. Wasn’t tracking it closely before, but it’s there. I’ll take it.
If you’re vegan, this one’s especially for you
Creatine is found in meat, poultry, and fish. If you eat none of those, you’re relying entirely on what your body produces on its own, which isn’t enough to saturate anything. If you’ve been running on low energy without a clear reason, this is worth looking into.
And yes, the hair loss thing
The fear comes from a single 2009 study in rugby players that found elevated DHT levels (DHT being linked to hair follicle damage). That study never measured actual hair loss, was never replicated, and a 12-week randomized controlled trial published in June 2025 found zero significant difference in DHT levels or hair outcomes between creatine and placebo. That fear isn’t the thing that should be stopping you.
What I’m using
Momentous Creatine is in heavy rotation right now. It’s clean, third-party tested, and mixes well. Create also makes gummies I’ve loved cycling in when I want to switch up the format. This is a trend I’m genuinely seeing value from. Do the research and see if it makes sense for you too.

Thania (TA Content Mgr)
This is for informational purposes only and is not medical advice. Consult a healthcare provider before starting any new supplement.